代表的業績

本庄 雅則

原著論文

  1. Honsho, M*., Abe, Y*., Imoto, Y., Chang, Z.F., Mandel, H., Falik-Zaccai, T.C., and Fujiki, Y.: Mammalian homologue NME3 of DYNAMO1 regulates peroxisome division. Int J Mol Sci. 21(21): 8040 (2020). (*共筆頭著者)
  2. Abe, Y., Nishimura, Y., Nakamura, K., Tamura, S., Honsho, M., Udo, H., Yamashita, T., and Fujiki, Y.: Peroxisome Deficiency Impairs BDNF Signaling and Memory. Front. Cell Dev. Biol. 8: 567017 (2020).
  3. Yamashita, K., Tamura, S., Honsho, M., Yada, H., Yagita, Y., Kosako, H., and Fujiki, Y.: Mitotic phosphorylation of Pex14p regulates peroxisomal import machinery. J. Cell Biol. 219(10): e202001003 (2020).
  4. Honsho, M., Tanaka, M., Zoeller, RA, and Fujiki, Y.: Distinct functions of acyl/alkyl dihydroxyacetonephosphate reductase in peroxisomes and endoplasmic reticulum. Front. Cell Dev. Biol. 8: 855 (2020).
  5. Abe, Y., Honsho, M., Kawaguchi, R., Matsuzaki, T., Ichiki, Y., Fujitani, M., Fujiwara, K.,  Hirokane, M., Oku, M., Sakai, Y., Yamashita, T., and Fujiki, Y.: A peroxisome deficiency-induced reductive cytosol state up-regulates the brain-derived neurotrophic factor pathway. J. Biol. Chem. 295(16): 5321-5334 (2020).
  6. Dubreuil, M.M., Morgens, D.W., Okumoto, K., Honsho, M., Contrepois, K., Lee-McMullen, B., Traber, G., Sood, R., Dixon, S.J., Snyder, M.P., Fujiki, Y., and Bassik, M.C.: Systematic identification of regulators of oxidative stress reveals non-canonical roles for peroxisomal import and the pentose phosphate pathway. Cell Rep. 30: 1417-1433.e7 (2020).
  7. Takahashi, T*., Honsho, M*., Abe, Y., and Fujiki, Y.: Plasmalogen mediates integration of adherens junction. J. Biochem. 166: 423-432 (2019).(*共筆頭著者)
  8. Honsho, M., Dorninger, F., Abe, Y., Setoyama, D., Ohgi, R., Uchiumi, T., Kang, D., Berger, J., and Fujiki, Y.: Impaired plasmalogen synthesis dysregulates liver X receptor-dependent transcription in cerebellum. J. Biochem. 166: 353-361 (2019).
  9. Exner, T., Romero-Brey, I., Yifrach, E., Rivera-Monroy, J., Schrul, B., Zouboulis, C.C., Stremmel, W., Honsho, M., Bartenschlager, R., Zalckvar, E., Poppelreuther, M., and Fullekrug, J.: An alternative membrane topology permits lipid droplet localization of peroxisomal fatty acyl-CoA reductase 1. J. Cell Sci. 132: jcs223016. (2019).
  10. Abe, Y., Honsho, M., Itoh, R., Kawaguchi, R., Fujitani, M., Fujiwara, K., Hirokane, M., Matsuzaki, T., Nakayama, K., Ohgi, R., Marutani, T., Nakayama, K.I., Yamashita, T., and Fujiki, Y.: Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of cerebellum. Life Sci. Alliance 1: e201800062 (2018).
  11. Imoto, Y., Abe, Y., Honsho, M., Okumoto, K., Ohnuma, M., Kuroiwa, H., Kuroiwa, T., and Fujiki, Y.: Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes. Nat. Commun. 9: 4634 (2018). 
  12. Honsho, M., Abe, Y., and Fujiki, Y.: Plasmalogen biosynthesis is spatiotemporally regulated by sensing plasmalogens in the inner leaflet of plasma membranes. Sci. Rep. 7: article 43936 (2017).
  13. Hossain, M. S., Abe, Y., Ali, F., Youssef, M., Honsho, M., Fujiki, Y., and Katafuchi, T.: Reduction of ether-type glycerophospholipids, plasmalogens, by NF-κB signal leading to microglial activation. J. Neurosci. 37: 4074-4092 (2017).
  14.  Imoto, Y., Abe, Y., Okumoto, K., Honsho, M., Kuroiwa, H., Kuroiwa, T., and Fujiki, Y.: Defining the dynamin-based ring organizing center on the peroxisome-dividing machinery isolated from Cyanidioschyzon merolae. J. Cell Sci. 130: 853-867 (2017). 
  15. Honsho, M., Abe, Y., and Fujiki,Y.: Dysregulation of plasmalogen homeostasis impairs cholesterol biosynthesis. J. Biol. Chem. 290: 28822-28833 (2015).
  16. Yoshida, Y., Niwa, H., Honsho, M., Itoyama, A., Fujiki, Y.: Pex11 mediates peroxisomal proliferation by promoting deformation of the lipid membrane. Biol. Open. 4: 710-721 (2015).
  17. Noguchi, M., Honsho, M., Abe, Y., Toyama, R., Niwa, H., Sato, Y., Ghaedi, K., Rahmanifar, A., Shafeghati, Y., and Fujiki, Y.: Mild reduction of plasmalogens causes rhizomelic chondrodysplasia punctata: Functional characterization of a novel mutation. J. Human Genet. 59: 387-392 (2014).
  18. Abe, Y., Honsho, M., Nakanishi, H., Taguchi, R., and Fujiki, Y.: Very-long-chain polyunsaturated fatty acids accumulate in phosphatidylcholine of fibroblasts from patients with Zellweger syndrome and acyl-CoA oxidase1 deficiency. Biochim. Biophys. Acta- Mol. Cell Biol. Lipids 1841: 610-619 (2014).
  19. Honsho, M., Asaoku, S., Fukumoto, K., and Fujiki, Y.: Topogenesis and Homeostasis of Fatty Acyl-CoA Reductase 1. J. Biol. Chem. 288: 34588-34598 (2013).
  20. Itoyama, A., Michiyuki, S., Honsho, M., Yamamoto, T., Moser, A., Yoshida, Y., and Fujiki, Y.: Mff functions with Pex11pβ and DLP1 in peroxisomal fission. Biol. Open. 2: 998-1006 (2013).
  21. Itoyama, A., Honsho, M., Abe, Y., Moser, A., Yoshida, Y., and Fujiki, Y.: Docosahexaenoic acid mediates peroxisomal elongation, a prerequisite for peroxisome division. J. Cell Sci. 125: 589-602 (2012).
  22. Honsho, M., Hashigushi, Y., Ghaedi, K., and Fujiki, Y.: Interaction defect of the medium isoform of PTS1-receptor Pex5p with PTS2-receptor Pex7p abrogates the PTS2 protein import into peroxisomes in mammals. J. Biochem. 149: 203-210 (2011).
  23. Honsho, M., Asaoku, S., and Fujiki, Y.: Posttranslational Regulation of Fatty Acyl-CoA Reductase 1, Far1, Controls Ether Glycerophospholipid Synthesis. J. Biol. Chem. 285: 8537-8542 (2010). “paper of the week”として掲載
  24. Honsho, M*., Yagita, Y*., Kinoshita, N. and Fujiki, Y.: Isolation and characterization of mutant animal cell line defective in alkyl-dihydroxyacetonephosphate synthase: Localization and transport of plasmalogens to post-Golgi compartments. Biochim Biophys Acta.-Mol. Cell Res. 1783: 1857-1865 (2008). (*共筆頭著者)
  25. Schneider, A., Rajendran, L., Honsho, M., Gralle, M., Donnert, G., Wouters, F., Hell, SW., and Simons, M.: Flotillin-Dependent Clustering of the Amyloid Precursor Protein Regulates Its Endocytosis and Amyloidogenic Processing in Neurons. J. Neurosci. 28: 2874-2882 (2008).
  26. Rajendran, L., Honsho, M., Zahn, TR, Keller, P., Geiger, KD., Verkade, P. and Simons, K.:  Alzheimer’s disease b-amyloid peptides are released in association with exosomes. Proc. Natl. Acad. Sci. USA. 103: 11172-11177 (2006).
  27. Schuck, S., Manninen, A., Honsho, M., Fullekrug, J. and Simons, K.: Generation of single and double knockdowns in polarized epithelial cells by retrovirus-mediated RNA interference. Proc. Natl. Acad. Sci. USA. 101: 4912-4917 (2004).
  28. Schuck, S*., Honsho, M*., Ekroos, K., Shevchenko, A. and Simons, K.: Resistance of cell membranes to different detergents. Proc. Natl. Acad. Sci. USA. 100: 5795-5800 (2003). (*共筆頭著者)
  29. Lahtinen, U., Honsho, M., Parton, RG., Simons, K. and Verkade, P.: Involvement of caveolin-2 in caveolar biogenesis in MDCK cells. FEBS Lett. 538: 85-88 (2003).
  30. Zhao, J., Onduka, T., Kinoshita, JY., Honsho, M., Kinoshita, T., Shimazaki, K., and Ito, A.: Dual Subcellular Distribution of Cytochrome b5 in Plant, Cauliflower, Cells. J. Biochem. 133: 115-121 (2003).
  31. Honsho, M., Hiroshige, T., and Fujiki, Y.: The Membrane Biogenesis Peroxin Pex16p. Topogenesis and Functional Roles in Peroxisomal Membrane Assembly. J. Biol. Chem. 277: 44513-44524 (2002).
  32. Honsho, M. and Fujiki, Y.: Topogenesis of Peroxisomal Membrane Protein Requires A Short, Positively Charged Intervening-loop Sequence and Flanking Hydrophobic Segments. STUDY USING HUMAN MEMBRANE PROTEIN PMP34. J. Biol. Chem. 276: 9375-9382 (2001).
  33. Ghaedi, K., Honsho, M., Shimozawa, N., Suzuki, Y., Kondo, N. and Fujiki, Y.: PEX3 is the Causal Gene Responsible for Peroxisome Membrane Assembly-defective Zellweger Syndrome of Complementation Group G. Am. J. Hum. Genet. 67: 976-981 (2000).
  34. Otera, H., Harano, T., Honsho, M., Ghaedi, K., Mukai, S., Tanaka, A., Kawai, A., Shimizu, N. and Fujiki, Y.: The Mammalian Peroxin Pex5pL, the Longer Isoform of the Mobile Peroxisome Targeting Signal (PTS) Type 1 Transporter, Translocates the Pex7p-PTS2 Protein Complex into Peroxisomes via Its Initial Docking Site, Pex14p. J. Biol. Chem. 275: 21703-21714 (2000).
  35. Honsho, M., Tamura, S., Shimozawa, N., Suzuki, Y., Kondo, N. and Fujiki, Y.: Mutation in PEX16 Is Causal in the Peroxisome-Deficient Zellweger Syndrome of Complementation Group D. Am. J. Hum. Genet. 63: 1622-1630 (1998).
  36. Kuroda, R., Ikenoue, T., Honsho, M., Tsujimoto, S., Mitoma, JY. and Ito, A.: Charged Amino Acids at the Carboxy-Terminal Portions Determine the Intracellular Locations of Two Isoforms of Cytochrome b5. J. Biol. Chem. 273: 31097-31102 (1998).
  37. Honsho, M., Mitoma, JY. and Ito, A.: Retention of Cytochrome b5 in the Endoplasmic Reticulum Is Transmembrane and Luminal Domain-dependent. J. Biol. Chem. 273: 20860-20866 (1998).
  38. Kuroda, R., Kinoshita, J., Honsho, M., Mitoma, JY. and Ito, A.: In situ Topology of Cytochrome b5 in the Endoplasmic Reticulum Membrane. J. Biochem. 120: 828-833 (1996).

著書

  1. Honsho, M., Okumoto, K., Tamura, S., and Fujiki, Y.: Peroxisome Biogenesis Disorders.: Lizard G. (eds) Peroxisome Biology: Experimental Models, Peroxisomal Disorders and Neurological Diseases. Advances in Experimental Medicine and Biology, Springer, Cham, vol. 1299, 45-54 (2020).
  2. Okumoto, K., Tamura, S., Honsho, M., and Fujiki, Y.: Peroxisome: Metabolic Functions and Biogenesis.: Lizard G. (eds) Peroxisome Biology: Experimental Models, Peroxisomal Disorders and Neurological Diseases. Advances in Experimental Medicine and Biology, Springer, Cham, vol. 1299, 3-17 (2020).
  3. Abe, Y., Tamura, S., Honsho, M., and Fujiki, Y.: A Mouse Model System to Study Peroxisomal Roles in Neurodegeneration of Peroxisome Biogenesis Disorders.: Lizard G. (eds) Peroxisome Biology: Experimental Models, Peroxisomal Disorders and Neurological Diseases. Advances in Experimental Medicine and Biology, Springer, Cham, vol. 1299,  119-143 (2020).
  4. 本庄雅則, 藤木幸夫: プラスマローゲン恒常性とその障害による疾患.: 医学のあゆみ 第5土曜特集『脂質クオリティ:研究の基礎と臨床』, 1103-1107 (2019). 医歯薬出版 令和元年6月
  5. Honsho, M. and Fujiki, Y.: Homeostasis of Plasmalogens in Mammals.: Encyclopedia of Food Chemistry, Elsevier Inc., Waltham, USA. vol. 2, pp.218-223 (2019). 
  6. 本庄雅則, 藤木幸夫: ペルオキシソームの恒常性と生理機能制御.: 生化学 特集:「オルガネラの生物機能と疾患における破綻機構」Vol. 90 No. 1, 5-13 (2018).日本生化学会 平成30年2月
  7. Honsho, M., and Fujiki, Y.: Analysis of Plasmalogen Synthesis in Cultured Cells.: Schrader, M. (ed.) Peroxisomes: Methods and Protocols, Methods in Molecular Biology (Series Ed.: Walker, J.M.), Springer, Humana Press, New York, USA pp. 55-61 (2017).
  8. Liu,Y., Honsho, M., and Fujiki, Y.: In Vitro PMP Import Analysis Using Cell-Free Synthesized PMP and Isolated Peroxisomes.: Schrader, M. (ed.) Peroxisomes: Methods and Protocols, Methods in Molecular Biology (Series Ed.: Walker, J.M.), Springer, Humana Press, New York, USA pp. 207-212 (2017).
  9. Okumoto, K., Honsho, M., Liu, Y., and Fujiki, Y.: Peroxisomal Membrane and Matrix Protein Import Using a Semi-Intact Mammalian Cell System.: Schrader, M. (ed.) Peroxisomes: Methods and Protocols, Methods in Molecular Biology (Series Ed.: Walker, J.M.), Springer, Humana Press, New York, USA pp. 213-219 (2017).
  10. Fujiki, Y., Okumoto, K., and Honsho, M.: Protein Import into Peroxisomes: The Principles and Methods of Studying (version 2.0).: Encyclopedia of Life Sciences, John Wiley & Sons, Chichester, UK, Published online: April 14, (2015). doi: 10.1002/9780470015902.a0002618.pub2
  11. 藤木幸夫, 山下俊一, 奥本寛治, 本庄雅則: ペキソファジー:ペルオキシソームの形成・機能制御と分解機構.: 実験医学 7月号特集「ユビキチン化を介したオルガネロファジー」, 1824-1831 (2017). 医歯薬出版 平成29年7月
  12. 藤木幸夫, 奥本寛治, 本庄雅則: ペルオキシソーム形成異常と疾患.: 別冊・医学のあゆみ 特集「ストレスシグナルと疾患―細胞恒常性維持機構の破綻と病態」75-79 (2016). 羊土社 平成28年7月
  13. 藤木幸夫, 本庄雅則: エーテルリン脂質プラスマローゲンの生合成とその障害.: 機能性食品と薬理栄養 特集「プラズマローゲンと神経機能」Vol. 9 No. 5, 322-327 (2016). 日本機能性食品医用学会誌 平成28年2月
  14. 藤木幸夫, 奥本寛治, 本庄雅則: ペルオキシソーム形成異常と疾患.: 医学のあゆみ 特集「細胞内小器官とストレス」Vol. 254 No. 5, 397-401 (2015). 医歯薬出版 平成27年8月
  15. Fujiki, Y., Itoyama, A., Abe, Y., and Honsho, M.:Molecular Complex Coordinating Peroxisome Morphogenesis in Mammalian Cells.: Brocard, C. and Hartig, A. (eds) Molecular machines involved in peroxisome biogenesis and maintenance, Springer-Verlag, Wien, Austria. pp. 391-401 (2014). doi: 10.1007/978-3-7091-1788-0
  16. 藤木幸夫, 本庄雅則: ペルオキシソームの脂質代謝.: 医学のあゆみ Vol. 248 No. 13, 1143-1149 (2014). 医歯薬出版 平成26年3月
  17. 藤木幸夫, 宮田暖, 奥本寛治, 田村茂彦, 糸山彰徳, 本庄雅則:ペルオキシソームの形成・制御とその障害.: 生体の科学 特集「細胞の分子構造と機能―核以外の細胞小器官」 Vol. 63 No. 5, 448-451 (2012). 医学書院 平成24年10月
  18. 藤木幸夫, 宮田暖, 松園裕嗣, 松崎高志, 本庄雅則: ペルオキシソームの形成・制御とその障害による高次機能の破綻: 実験医学 Vol. 28 No. 13, 2094-2101 (2010) 羊土社 平成22年8月
  19. Schuck, S., Honsho, M., and Simons, K.: Detergent-Resistant Membranes and the Use of Cholesterol Depletion. In Cell Biology: A Laboratory Handbook 2, 5-9 (2006). Elsevier Inc
  20. 藤木幸夫, 向井悟, 本庄雅則: ペルオキシソーム形成の分子基盤: 実験医学増刊 Vol. 21 No. 14,  1904-1911 (2003) 羊土社 平成15年9月

 

総説

  1. Imoto, Y., Abe, Y., Honsho, M., Okumoto, K., Ohnuma, M., Kuroiwa, H., Kuroiwa, T., and Fujiki, Y.: Molecular basis of local energy generation during mitochondrial and peroxisomal division. PLANT MORPHOLOGY 32(1): 59-73 (2020)
  2. Fujiki, Y., Abe, Y., Imoto, Y., Tanaka, A.J., Okumoto, K., Honsho, M., Tamura, S., Miyata, N., Yamashita, T., Chung, W.K., and Kuroiwa, T.: Recent insights into peroxisome biogenesis and associated disease. J. Cell Sci. 133: jcs236943 (2020).
  3. Honsho, M. and Fujiki, Y.:”Focus on Plasmalogens” issue: Plasmalogen homeostasis: regulation of plasmalogen biosynthesis and its physiological consequence in mammals. FEBS Lett. 591: 2720-2729 (2017).
  4. Honsho, M*., Yamashita, S*., and Fujiki, Y.: Peroxisome homeostasis: Mechanisms of division and selective degradation of peroxisomes in mammals. Biochim Biophys Acta.-Mol. Cell Res. 1863: 984-991 (2016). (*共筆頭著者)
  5. Fujiki, Y., Okumoto, K., Mukai, S., Honsho, M., and Tamura, S.: Peroxisome biogenesis in mammalian cells. Front. Physiol. Vol. 5 Article 307: 1-8 Epub. (2014).

稗田 道成

2020年度以前に講座で発表された業績