代表的業績

本庄 雅則

原著論文

  1. Honsho M.*, Abe Y.*, Imoto Y., Chang Z.F., Mandel H., Falik-Zaccai T.C., and Fujiki Y.: Mammalian homologue NME3 of DYNAMO1 regulates peroxisome division. Int J Mol Sci. 21(21): 8040 (2020). (*共筆頭著者)
  2. Abe Y., Nishimura Y., Nakamura K., Tamura S., Honsho M., Udo H., Yamashita T., and Fujiki Y.: Peroxisome Deficiency Impairs BDNF Signaling and Memory. Front. Cell Dev. Biol. 8: 567017 (2020).
  3. Yamashita K., Tamura S., Honsho M., Yada H., Yagita Y., Kosako H., and Fujiki Y.: Mitotic phosphorylation of Pex14p regulates peroxisomal import machinery. J. Cell Biol. 219(10): e202001003 (2020).
  4. Honsho M., Tanaka M., Zoeller RA, and Fujiki Y.: Distinct functions of acyl/alkyl dihydroxyacetonephosphate reductase in peroxisomes and endoplasmic reticulum. Front. Cell Dev. Biol. 8: 855 (2020).
  5. Abe Y., Honsho M., Kawaguchi R., Matsuzaki T., Ichiki Y., Fujitani M., Fujiwara K.,  Hirokane M., Oku M., Sakai Y., Yamashita T., and Fujiki Y.: A peroxisome deficiency-induced reductive cytosol state up-regulates the brain-derived neurotrophic factor pathway. J. Biol. Chem. 295(16): 5321-5334  (2020).
  6. Imoto, Y., Abe, Y., Honsho, M., Okumoto, K., Ohnuma, M., Kuroiwa, H., Kuroiwa, T., and Fujiki, Y.: Molecular basis of local energy generation during mitochondrial and peroxisomal division. Plant Morphology, in press (2020).
  7. Dubreuil, M.M., Morgens, D.W., Okumoto, K., Honsho, M., Contrepois, K., Lee-McMullen, B., Traber, G., Sood, R., Dixon, S.J., Snyder, M.P., Fujiki, Y., and Bassik, M.C.: Systematic identification of regulators of oxidative stress reveals non-canonical roles for peroxisomal import and the pentose phosphate pathway. Cell Rep. 30: 1417-1433.e7 (2020).
  8. Takahashi, Y*., Honsho, M*., Abe, Y., and Fujiki, Y.: Plasmalogen mediates integration of adherens junction. J. Biochem. 166: 423-432 (2019).(*共筆頭著者)
  9. Honsho, M., Dorninger, F., Abe, Y., Setoyama, D., Ohgi, R., Uchiumi, T., Kang, D., Berger, J., and Fujiki, Y.: Impaired plasmalogen synthesis dysregulates liver X receptor-dependent transcription in cerebellum. J. Biochem. 166: 353-361 (2019).
  10. Exner, T., Romero-Brey, I., Yifrach, E., Rivera-Monroy, J., Schrul, B., Zouboulis, C.C., Stremmel, W., Honsho, M., Bartenschlager, R., Zalckvar, E., Poppelreuther, M., and Fullekrug, J. An alternative membrane topology permits lipid droplet localization of peroxisomal fatty acyl-CoA reductase 1. J. Cell Sci. 132: jcs223016.
  11. Abe, Y., Honsho, M., Itoh, R., Kawaguchi, R., Fujitani, M., Fujiwara, K., Hirokane, M., Matsuzaki, T., Nakayama, K., Ohgi, R., Marutani, T., Nakayama, K.I., Yamashita, T., and Fujiki, Y.: Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of cerebellum. Life Sci. Alliance 1: e201800062 (2018).
  12. Imoto, Y., Abe, Y., Honsho, M., Okumoto, K., Ohnuma, M., Kuroiwa, H., Kuroiwa, T., and Fujiki, Y.: Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes. Nat. Commun. 9: 4634 (2018). 
  13. Honsho, M., Abe, Y., and Fujiki, Y.: Plasmalogen biosynthesis is spatiotemporally regulated by sensing plasmalogens in the inner leaflet of plasma membranes. Sci. Rep. 7: article 43936 (2017).
  14. Hossain, M. S., Abe, Y., Ali, F., Youssef, M., Honsho, M., Fujiki, Y., and Katafuchi, T.: Reduction of ether-type glycerophospholipids, plasmalogens, by NF-κB signal leading to microglial activation. J. Neurosci. 37: 4074-4092 (2017).
  15. Imoto, Y., Abe, Y., Okumoto, K., Honsho, M., Kuroiwa, H., Kuroiwa, T., and Fujiki, Y.: Defining dynamin-based ring organizing center on the peroxisome-dividing machinery isolated from Cyanidioschyzon merolae. J. Cell Sci. 130: 853-867 (2017).
  16. Honsho, M., Abe, Y., and Fujiki,Y.: Dysregulation of plasmalogen homeostasis impairs cholesterol biosynthesis. J. Biol. Chem. 290: 28822-28833 (2015).
  17. Yoshida, Y., Niwa, H., Honsho, M., Itoyama, A., Fujiki, Y.: Pex11 mediates peroxisomal proliferation by promoting deformation of the lipid membrane. Biol. Open. 4: 710-721 (2015).
  18. Noguchi, M., Honsho, M., Abe, Y., Toyama, R., Niwa, H., Sato, Y., Ghaedi, K., Rahmanifar, A., Shafeghati, Y., and Fujiki, Y.: Mild reduction of plasmalogens causes rhizomelic chondrodysplasia punctata: Functional characterization of a novel mutation. J. Human Genet. 59: 387-392 (2014).
  19. Abe, Y., Honsho, M., Nakanishi, H., Taguchi, R., and Fujiki, Y. Very-long-chain polyunsaturated fatty acids accumulate in phosphatidylcholine of fibroblasts from patients with Zellweger syndrome and acyl-CoA oxidase1 deficiency. Biochim. Biophys. Acta- Mol. Cell Biol. Lipids 1841: 610-619 (2014).
  20. Honsho, M., Asaoku, S., Fukumoto, K., and Fujiki, Y. Topogenesis and Homeostasis of Fatty Acyl-CoA Reductase 1. J. Biol. Chem. 288: 34588-34598 (2013).
  21. Itoyama, A., Michiyuki, S., Honsho, M., Yamamoto, T., Moser, A., Yoshida, Y., and Fujiki, Y. Mff functions with Pex11pβ and DLP1 in peroxisomal fission. Biol. Open. 2: 998-1006 (2013).
  22. Itoyama, A., Honsho, M., Abe, Y., Moser, A., Yoshida, Y., and Fujiki, Y. Docosahexaenoic acid mediates peroxisomal elongation, a prerequisite for peroxisome division. J. Cell Sci. 125: 589-602 (2012).
  23. Honsho, M., Hashigushi, Y., Ghaedi, K., and Fujiki, Y. Interaction defect of the medium isoform of PTS1-receptor Pex5p with PTS2-receptor Pex7p abrogates the PTS2 protein import into peroxisomes in mammals. J. Biochem. 149: 203-210 (2011).
  24. Honsho, M., Asaoku, S., and Fujiki, Y. Posttranslational Regulation of Fatty Acyl-CoA Reductase 1, Far1, Controls Ether Glycerophospholipid Synthesis. J. Biol. Chem. 285: 8537-8542 (2010). “paper of the week”として掲載
  25. Honsho, M*., Yagita, Y*., Kinoshita, N. and Fujiki, Y. Isolation and characterization of mutant animal cell line defective in alkyl-dihydroxyacetonephosphate synthase: Localization and transport of plasmalogens to post-Golgi compartments. Biochim Biophys Acta.-Mol. Cell Res. 1783: 1857-1865 (2008). (*共筆頭著者)
  26. Schneider, A., Rajendran, L., Honsho, M., Gralle, M., Donnert, G., Wouters, F., Hell, SW., and Simons, M. Flotillin-Dependent Clustering of the Amyloid Precursor Protein Regulates Its Endocytosis and Amyloidogenic Processing in Neurons. J. Neurosci. 28: 2874-2882 (2008).
  27. Rajendran, L., Honsho, M., Zahn, TR, Keller, P., Geiger, KD., Verkade, P. and Simons, K.  Alzheimer’s disease b-amyloid peptides are released in association with exosomes. Proc. Natl. Acad. Sci. USA. 103: 11172-11177 (2006).
  28. Schuck, S., Manninen, A., Honsho, M., Fullekrug, J. and Simons, K. Generation of single and double knockdowns in polarized epithelial cells by retrovirus-mediated RNA interference. Proc. Natl. Acad. Sci. USA. 101: 4912-4917 (2004).
  29. Schuck, S*., Honsho, M*., Ekroos, K., Shevchenko, A. and Simons, K. Resistance of cell membranes to different detergents. Proc. Natl. Acad. Sci. USA. 100: 5795-5800 (2003). (*共筆頭著者)
  30. Lahtinen, U., Honsho, M., Parton, RG., Simons, K. and Verkade, P. Involvement of caveolin-2 in caveolar biogenesis in MDCK cells. FEBS Lett. 538: 85-88 (2003).
  31. Zhao J, Onduka T, Kinoshita JY, Honsho M, Kinoshita T, Shimazaki K, and Ito A. Dual Subcellular Distribution of Cytochrome b5 in Plant, Cauliflower, Cells. J. Biochem. 133: 115-121 (2003).
  32. Honsho, M., Hiroshige, T., and Fujiki, Y. The Membrane Biogenesis Peroxin Pex16p. Topogenesis and Functional Roles in Peroxisomal Membrane Assembly. J. Biol. Chem. 277: 44513-44524 (2002).
  33. Honsho, M. and Fujiki, Y. Topogenesis of Peroxisomal Membrane Protein Requires A Short, Positively Charged Intervening-loop Sequence and Flanking Hydrophobic Segments. STUDY USING HUMAN MEMBRANE PROTEIN PMP34. J. Biol. Chem. 276: 9375-9382 (2001).
  34. Ghaedi, K., Honsho, M., Shimozawa, N., Suzuki, Y., Kondo, N. and Fujiki, Y. PEX3 is the Causal Gene Responsible for Peroxisome Membrane Assembly-defective Zellweger Syndrome of Complementation Group G. Am. J. Hum. Genet. 67: 976-981 (2000).
  35. Otera, H., Harano, T., Honsho, M., Ghaedi, K., Mukai, S., Tanaka, A., Kawai, A., Shimizu, N. and Fujiki, Y. The Mammalian Peroxin Pex5pL, the Longer Isoform of the Mobile Peroxisome Targeting Signal (PTS) Type 1 Transporter, Translocates the Pex7p-PTS2 Protein Complex into Peroxisomes via Its Initial Docking Site, Pex14p. J. Biol. Chem. 275: 21703-21714 (2000).
  36. Honsho, M., Tamura, S., Shimozawa, N., Suzuki, Y., Kondo, N. and Fujiki, Y. Mutation in PEX16 Is Causal in the Peroxisome-Deficient Zellweger Syndrome of Complementation Group D. Am. J. Hum. Genet. 63: 1622-1630 (1998).
  37. Kuroda, R., Ikenoue, T., Honsho, M., Tsujimoto, S., Mitoma, JY. and Ito, A. Charged Amino Acids at the Carboxy-Terminal Portions Determine the Intracellular Locations of Two Isoforms of Cytochrome b5. J. Biol. Chem. 273: 31097-31102 (1998).
  38. Honsho, M., Mitoma, JY. and Ito, A. Retention of Cytochrome b5 in the Endoplasmic Reticulum Is Transmembrane and Luminal Domain-dependent. J. Biol. Chem. 273: 20860-20866 (1998).
  39. Kuroda, R., Kinoshita, J., Honsho, M., Mitoma, JY. and Ito, A. In situ Topology of Cytochrome b5 in the Endoplasmic Reticulum Membrane. J. Biochem. 120: 828-833 (1996).

著書

  1. Okumoto, K., Tamura, S., Honsho, M., and Fujiki, Y.: Peroxisome: metabolic functions and biogenesis. In: Lizard, G. (ed.) Peroxisomes in Neurodegenerative Diseases, Springer Nature, Berlin Heidelberg New York., in press (2020).
  2. Honsho, M., Okumoto, K., Tamura, S., and Fujiki, Y.: Peroxisome biogenesis disorders. In: Lizard, G. (ed.) Peroxisomes in Neurodegenerative Diseases, Springer Nature, Berlin Heidelberg New York., in press (2020).
  3. Abe, Y., Tamura, S., Honsho, M., and Fujiki, Y.: A mouse model system to study peroxisomal roles in neurodegeneration of peroxisome biogenesis disorders. In: Lizard, G. (ed.) Peroxisomes in Neurodegenerative Diseases, Springer Nature, Berlin Heidelberg New York., in press (2020).
  4. 本庄雅則, 藤木幸夫: プラスマローゲン恒常性とその障害による疾患. 医学のあゆみ 第5土曜特集『脂質クオリティ:研究の基礎と臨床』, 1103-1107 (2019). 医歯薬出版 令和元年6月
  5. Honsho, M. and Fujiki, Y.: Homeostasis of plasmalogens in mammals. In Encyclopedia of Food Chemistry, Elsevier Inc., Waltham, USA. vol. 2, pp.218-223 (2019). https://doi.org/10.1016/B978-0-08-100596-5.21664-8
  6. 本庄雅則, 藤木幸夫: ペルオキシソームの恒常性と生理機能制御. 生化学 特集:「オルガネラの生物機能と疾患における破綻機構」Vol. 90 No. 1, 5-13 (2018).日本生化学会 平成30年2月
  7. Honsho, M., and Fujiki, Y.: Analysis of plasmalogen synthesis in cultured cells. In: Schrader, M. (ed.) Peroxisomes: Methods and Protocols, Methods in Molecular Biology (Series Ed.: Walker, J.M.), Springer, Humana Press, New York, USA (2016) pp. 55-61 (2017).
  8. Liu,Y., Honsho, M., and Fujiki, Y.: In vitro PMP import analysis using cell-free synthesized PMP and isolated peroxisomes. In: Schrader, M. (ed.) Peroxisomes: Methods and Protocols, Methods in Molecular Biology (Series Ed.: Walker, J.M.), Springer, Humana Press, New York, USA pp. 207-212 (2017).
  9. Okumoto, K., Honsho, M., Liu, Y., and Fujiki, Y.: Peroxisomal membrane and matrix protein import using a semi-intact mammalian cell system. In: Schrader, M. (ed.) Peroxisomes: Methods and Protocols, Methods in Molecular Biology (Series Ed.: Walker, J.M.), Springer, Humana Press, New York, USA pp. 213-219 (2017)
  10. Fujiki, Y., Okumoto, K., and Honsho, M.: Protein Import into Peroxisomes: the principles and methods of studying (version 2.0). Encyclopedia of Life Sciences, John Wiley & Sons, Chichester, UK, Published online: April 14, (2015). doi: 10.1002/9780470015902.a0002618.pub2
  11. 藤木幸夫, 山下俊一, 奥本寛治, 本庄雅則: ペキソファジー:ペルオキシソームの形成・機能制御と分解機構. 実験医学 7月号特集「ユビキチン化を介したオルガネロファジー」, 1824-1831 (2017). 医歯薬出版 平成29年7月
  12. 藤木幸夫, 奥本寛治, 本庄雅則: ペルオキシソーム形成異常と疾患. 別冊・医学のあゆみ 特集「ストレスシグナルと疾患―細胞恒常性維持機構の破綻と病態」75-79 (2016). 羊土社 平成28年7月
  13. 藤木幸夫, 本庄雅則: エーテルリン脂質プラスマローゲンの生合成とその障害. 機能性食品と薬理栄養 特集「プラズマローゲンと神経機能」Vol. 9 No. 5, 322-327 (2016). 日本機能性食品医用学会誌 平成28年2月
  14. 藤木幸夫, 奥本寛治, 本庄雅則: ペルオキシソーム形成異常と疾患. 医学のあゆみ 特集「細胞内小器官とストレス」Vol. 254 No. 5, 397-401 (2015). 医歯薬出版 平成27年8月
  15. Fujiki, Y., Itoyama, A., Abe, Y., and Honsho, M.:Molecular Complex Coordinating Peroxisome Morphogenesis in Mammalian Cells. In: Brocard, C. and Hartig, A. (eds) Molecular machines involved in peroxisome biogenesis and maintenance, Springer-Verlag, Wien, Austria. pp. 391-401 (2014). doi: 10.1007/978-3-7091-1788-0
  16. 藤木幸夫、本庄雅則:ペルオキシソームの脂質代謝. 医学のあゆみ Vol. 248 No. 13, 1143-1149 (2014). 医歯薬出版 平成26年3月
  17. 藤木幸夫、宮田暖、奥本寛治、田村茂彦、糸山彰徳、本庄雅則:ペルオキシソームの形成・制御とその障害. 生体の科学 特集「細胞の分子構造と機能―核以外の細胞小器官」 Vol. 63 No. 5, 448-451 (2012). 医学書院 平成24年10月
  18. 藤木幸夫、宮田暖、松園裕嗣、松崎高志、本庄雅則:ペルオキシソームの形成・制御とその障害による高次機能の破綻  実験医学 Vol. 28 No. 13, 2094-2101 (2010) 羊土社 平成22年8月
  19. Detergent-resistant membranes and the use of cholesterol depletion. Schuck, S., Honsho, M., and Simons, K. In Cell Biology: A Laboratory Handbook 2, 5-9 (2006). Elsevier Inc
  20. 藤木幸夫、向井悟、本庄雅則ペルオキシソーム形成の分子基盤 実験医学増刊 Vol. 21 No. 14,  1904-1911 (2003) 羊土社 平成15年9月

 

総説

  1. Fujiki, Y., Abe, Y., Imoto, Y., Tanaka, A.J., Okumoto, K., Honsho, M., Tamura, S., Miyata, N., Yamashita, T., Chung, W.K., and Kuroiwa, T.: Recent insights into peroxisome biogenesis and associated disease. J. Cell Sci. 133: jcs236943 (2020).
  2. Honsho, M. and Fujiki, Y.:”Focus on Plasmalogens” issue: Plasmalogen homeostasis: regulation of plasmalogen biosynthesis and its physiological consequence in mammals. FEBS Lett. 591: 2720-2729 (2017).
  3. Honsho, M*., Yamashita, S*., and Fujiki, Y. Peroxisome homeostasis: mechanisms of division and selective degradation of peroxisomes in mammals. Biochim Biophys Acta.-Mol. Cell Res. 1863: 984-991 (2016). (*共筆頭著者)
  4. Fujiki, Y., Okumoto, K., Mukai, S., Honsho, M., and Tamura, S.: Peroxisome biogenesis in mammalian cells. Front. Physiol. Vol. 5 Article 307: 1-8 Epub. (2014).
  5. Imoto, Y., Abe, Y., Honsho, M., Okumoto, K., Ohnuma, M., Kuroiwa, H., Kuroiwa, T., and Fujiki, Y.: Molecular basis of local energy generation during mitochondrial and peroxisomal division. PLANT MORPHOLOGY 32(1): 59-73 (2020)

稗田 道成

2020年度以前に講座で発表された業績